5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

Base Information

• Chemical Name: 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester
• CAS No.: 476209-86-6
• Molecular Formula: C₂₂H₂₈FIO₃Si
• Molecular Weight: 514.451
• Mol file: 476209-86-6.mol

Synonyms:5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

Chemical Property of 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

There total 3 articles about 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one → 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester (476209-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: NaOH

3: I₂; PPh₃; imidazole

With 1H-imidazole; sodium hydroxide; hydrogen; iodine; triphenylphosphine; palladium on activated charcoal;

DOI:10.1081/NCN-120021965

Reference yield:

(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester (1028289-72-6) → 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester (476209-86-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In toluene; at 60 ℃; for 4h;

DOI:10.1021/jm020246+

Reference yield:

5-(tert-butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester → 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester (476209-86-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine;

DOI:10.1081/NCN-120021965

upstream raw materials:

(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

Downstream raw materials:

(2S,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-2-phenylselenyl-γ-thiobutyrolactone

(1S/R,2S,4R)-1-O-aceyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselenyl-4-thio-β-L-ribofuranoside

(3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-dihydro-thiophen-2-one

(3S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-dihydro-thiophen-2-one