Technology Process of 2-(3-cyano-4-fluorophenyl)propanoic acid
There total 7 articles about 2-(3-cyano-4-fluorophenyl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 2-(3-cyano-4-fluorophenyl)propanoate;
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 0 - 23 ℃;
for 2h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C
2: nitric acid; sulfuric acid / ethyl acetate / 0.67 h / 0 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
4: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / water; acetonitrile / 16.17 h / 10 - 20 °C
5: N,N-dimethyl-formamide / 7 h / 140 °C
6: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C
With
sulfuric acid; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; nitric acid; sodium hydride; potassium iodide; lithium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
2: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / water; acetonitrile / 16.17 h / 10 - 20 °C
3: N,N-dimethyl-formamide / 7 h / 140 °C
4: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C
With
palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; potassium iodide; lithium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
