2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Base Information

Chemical Name:2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1428790-47-9
Molecular Formula:C₂₃H₂₄F₄N₄O
Molecular Weight:448.463
Hs Code.:

Synonyms:2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Property of 2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Technology Process of 2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 8 articles about 2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 935518-29-9
(2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1428790-46-8
2-(3-cyano-4-fluorophenyl)propanoic acid

: 1428790-47-9
2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; at 23 ℃;

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1428790-47-9
2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

2: nitric acid; sulfuric acid / ethyl acetate / 0.67 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

4: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / water; acetonitrile / 16.17 h / 10 - 20 °C

5: N,N-dimethyl-formamide / 7 h / 140 °C

6: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

7: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 1,4-dioxane / 20 °C / Cooling with ice

With sulfuric acid; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; nitric acid; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; lithium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1374574-62-5
methyl 2-(3-cyano-4-fluorophenyl)propanoate

: 1428790-47-9
2-(3-cyano-4-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

2: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 1,4-dioxane / 20 °C / Cooling with ice

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;