N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

Base Information

Chemical Name:N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide
CAS No.:1217339-09-7
Molecular Formula:C₁₉H₁₇FN₂O₄S
Molecular Weight:388.419
Hs Code.:

Synonyms:N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

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Chemical Property of N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

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Technology Process of N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

There total 3 articles about N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1217339-08-6
2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1217339-09-7
N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1217340-86-7
methyl 2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxylate

: 1217339-09-7
N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol; tetrahydrofuran / 60 - 67 °C

2: ammonia; HATU / N,N-dimethyl-formamide; methanol / 1 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane; tetrahydrofuran / 1 h / 0 °C

With ammonia; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 691857-10-0
2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

: 1217339-09-7
N-(3-cyano-2-(4-fluorophenyl)-5-isopropoxybenzofuran-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia; HATU / N,N-dimethyl-formamide; methanol / 1 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane; tetrahydrofuran / 1 h / 0 °C

With ammonia; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;