(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Base Information

Chemical Name:(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide
CAS No.:367909-82-8
Molecular Formula:C₃₃H₃₂O₇
Molecular Weight:540.613
Hs Code.:

Synonyms:(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Suppliers and Price of (2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

There total 1 articles about (2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 326606-31-9
(3R,4S)-3-hydroxy-5-trityloxy-4-pentanolide

: 367909-82-8
(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

: (4R,5S)-3-[(3,4-Dimethoxy-phenyl)-hydroxy-methyl]-4-hydroxy-5-trityloxymethyl-dihydro-furan-2-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -75 ℃; for 1h;
DOI:10.1271/bbb.65.1559

Reference yield: 81.0%

: 107-30-2
chloromethyl methyl ether

: 367909-82-8
(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

: 367909-83-9
(2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Guidance literature:: With diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1271/bbb.65.1559

Reference yield:

: 367909-82-8
(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

: 367909-84-0
(2S,3R,4R,5R)-3,5-bis(methoxymethoxy)-5-(3,4-dimethoxyphenyl)-4-pivaloyloxymethyl-1-trityloxy-2-pentanol

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / (i-Pr)2NH / CH₂Cl₂ / 3 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

3: pyridine / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1271/bbb.65.1559