(2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Base Information

• Chemical Name: (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide
• CAS No.: 367909-83-9
• Molecular Formula: C₃₇H₄₀O₉
• Molecular Weight: 628.719

Synonyms:(2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Chemical Property of (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

There total 3 articles about (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

chloromethyl methyl ether (107-30-2) + (2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide (367909-82-8) → (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide (367909-83-9)

Guidance literature:

With diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1271/bbb.65.1559

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide (367909-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / 1 h / -75 °C

2: 81 percent / (i-Pr)2NH / CH₂Cl₂ / 3 h / 20 °C

With diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1271/bbb.65.1559

Reference yield:

(3R,4S)-3-hydroxy-5-trityloxy-4-pentanolide (326606-31-9) → (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide (367909-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / 1 h / -75 °C

2: 81 percent / (i-Pr)2NH / CH₂Cl₂ / 3 h / 20 °C

With diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1271/bbb.65.1559

upstream raw materials:

chloromethyl methyl ether

(2R,3R,4S)-3-hydroxy-2-[(1R)-1-hydroxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

3,4-dimethoxy-benzaldehyde

(3R,4S)-3-hydroxy-5-trityloxy-4-pentanolide

Downstream raw materials:

(2S,3R,4R,5R)-3,5-bis(methoxymethoxy)-5-(3,4-dimethoxyphenyl)-4-pivaloyloxymethyl-1-trityloxy-2-pentanol

(2S,3R,4R,5R)-3,5-bis(methoxymethoxy)-5-(3,4-dimethoxyphenyl)-4-pivaloyloxymethyl-1,2-pentanediol

(2S,3R,4R)-4-(3,4-dimethoxyphenyl)-2-phenoxythiocarbonyloxy-3-pivaloyloxymethyl-4-butanolide

(2R,3R,4R)-2,4-bis(methoxymethoxy)-4-(3,4-dimethoxyphenyl)-3-pivaloyloxymethylbutanal

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 367909-83-9 (2R,3R,4S)-3-methoxymethoxy-2-[(1R)-1-methoxymethoxy-1-(3,4-dimethoxyphenyl)methyl]-5-trityloxy-4-pentanolide

Send

Send

Metric Ton KG G Pound L ML

Send

Send