methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate

Base Information

• Chemical Name: methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate
• CAS No.: 884868-05-7
• Molecular Formula: C₁₇H₁₉NO₃S₂
• Molecular Weight: 349.475
• Mol file: 884868-05-7.mol

Synonyms:methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate

Chemical Property of methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate

There total 4 articles about methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-(ethylthio)phenyl)thiophene-2-carboxylic acid (884867-80-5) + methyl 3-aminopropanoate hydrochloride (3196-73-4) → methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate (884868-05-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/ja057699z

Reference yield:

(3-(ethylthio)phenyl)boronic acid (870718-05-1) → methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate (884868-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Pd(PPh₃)4; aq. Na₂CO₃ / dioxane / 4 h / 80 °C

2: 99 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 5 h / 20 °C

3: EDCI; Et₃N / CH₂Cl₂ / 5 h / 20 °C

With lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1: Suzuki cross-coupling;

DOI:10.1021/ja057699z

Reference yield:

methyl 5-(3-(ethylthio)phenyl)thiophene-2-carboxylate (884867-93-0) → methyl 3-(2-(3-(ethylthio)phenyl)thiophene-5-carboxamido)propanoate (884868-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 5 h / 20 °C

2: EDCI; Et₃N / CH₂Cl₂ / 5 h / 20 °C

With lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ja057699z

upstream raw materials:

5-(3-(ethylthio)phenyl)thiophene-2-carboxylic acid

methyl 3-aminopropanoate hydrochloride

(3-(ethylthio)phenyl)boronic acid

methyl 5-(3-(ethylthio)phenyl)thiophene-2-carboxylate