N-(N⁴-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester

Base Information

• Chemical Name: N-(N⁴-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester
• CAS No.: 149376-83-0
• Molecular Formula: C₂₅H₃₃N₅O₈
• Molecular Weight: 531.566
• Mol file: 149376-83-0.mol

Synonyms:N-(N⁴-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester

Chemical Property of N-(N⁴-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N⁴-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester

There total 4 articles about N-(N⁴-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N4-(Z)-1-(carboxymethyl)cytosine pentafluorophenyl ester (149035-03-0) + N-(2-((Boc)amino)ethyl)-β-alanine methyl ester hydrochloride → N-(N4-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester (149376-83-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja00097a002

Reference yield:

[N4-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid (144564-95-4) → N-(N4-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester (149376-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / N,N'-dicyclohexylcarbodiimide / dimethylformamide / 3 h / Ambient temperature

2: 64 percent / triethylamine / dimethylformamide

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/ja00097a002

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) → N-(N4-(Z)-1-cytosylacetyl)-N-(2-((Boc)amino)ethyl)-β-alanine methyl ester (149376-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 20 h / Heating

2: Et₃N / dimethylformamide / 20 h

With triethylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c39930000518

upstream raw materials:

methyl 3-((2-((tertbutoxycarbonyl)amino)ethyl)amino)propanoate

N⁴-(Z)-1-(carboxymethyl)cytosine pentafluorophenyl ester

[N⁴-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid

N-BOC-1,2-diaminoethane