1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

Base Information

Chemical Name:1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid
CAS No.:212489-07-1
Molecular Formula:C₂₁H₂₁NO₈
Molecular Weight:415.4
Hs Code.:

Synonyms:1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

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Chemical Property of 1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

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Technology Process of 1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

There total 7 articles about 1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 212501-20-7
6,7-dimethoxy-4-(3,4,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

: 212489-07-1
1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

Guidance literature:: 6,7-dimethoxy-4-(3,4,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid; With ammonium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In ethyl acetate; at 20 ℃; Further stages.;
DOI:10.1021/jm000558h

Reference yield:

: 97081-13-5
3,4-dimethoxy-6-(3,4,5-trimethoxybenzoyl)benzoic acid

: 212489-07-1
1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 20 °C

2.1: 4 N HCl / ethyl acetate / 20 °C

2.2: AcOH / dioxane / 6 h / Heating

3.1: 5 N NH₃ / methanol / 20 °C

3.2: 91 percent / 4 N HCl / ethyl acetate / 20 °C

With hydrogenchloride; ammonium hydroxide; potassium carbonate; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: 5658-49-1
N,N-dimethyl(3,4,5-trimethoxyphenyl)carboxamide

: 212489-07-1
1,2-dihydro-6,7-dimethoxy-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -40 °C

2.1: 2 N HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 6 h / Heating

6.1: 5 N NH₃ / methanol / 20 °C

6.2: 91 percent / 4 N HCl / ethyl acetate / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; recorcinol; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h