3,4,5-trimethoxy-N,N-dimethylbenzamide

Base Information

• Chemical Name: 3,4,5-trimethoxy-N,N-dimethylbenzamide
• CAS No.: 5658-49-1
• Molecular Formula: C12H17NO4
• Molecular Weight: 239.271
• Mol file: 5658-49-1.mol

Synonyms:

Chemical Property of 3,4,5-trimethoxy-N,N-dimethylbenzamide

Chemical Property:

• Vapor Pressure: 2.23E-06mmHg at 25°C
• Boiling Point: 392.8°Cat760mmHg
• Flash Point: 191.4°C
• Density: 1.103g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4,5-trimethoxy-N,N-dimethylbenzamide

There total 5 articles about 3,4,5-trimethoxy-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + dimethyl amine (124-40-3) → N,N-dimethyl(3,4,5-trimethoxyphenyl)carboxamide (5658-49-1)

Guidance literature:

With manganese(IV) oxide; sodium cyanide; In chloroform; isopropyl alcohol; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00969-8

Reference yield: 73.0%

N,N-dimethylammonium chloride (506-59-2) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → N,N-dimethyl(3,4,5-trimethoxyphenyl)carboxamide (5658-49-1)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) ferrite; calcium carbonate; In water; acetonitrile; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tet.2014.01.051

Reference yield:

dimethyl amine (124-40-3) + Eudesmic acid (118-41-2) → N,N-dimethyl(3,4,5-trimethoxyphenyl)carboxamide (5658-49-1)

Guidance literature:

Eudesmic acid; With thionyl chloride; In chloroform; for 3h; Inert atmosphere; Reflux;

dimethyl amine; In water; at 0 ℃; for 2h;

DOI:10.1039/c6cc03423c

upstream raw materials:

3,4,5-Trimethoxybenzoyl chloride

diethylamine

3,4,5-trimethoxy-benzaldehyde

dimethyl amine

Downstream raw materials:

N,N-dimethyl-1-(3,4,5-trimethoxyphenyl)methanamine

3,4,5-trimethoxybenzoic acid methyl ester

3,4-dimethoxy-6-(3,4,5-trimethoxybenzoyl)benzaldehyde dimethyl acetal

3-benzyloxy-6-(3,4,5-trimethoxybenzoyl)benzaldehyde dimethyl acetal