tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate

Base Information

• Chemical Name: tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate
• CAS No.: 1208114-02-6
• Molecular Formula: C₁₉H₂₈O₃Si
• Molecular Weight: 332.515
• Mol file: 1208114-02-6.mol

Synonyms:tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate

Chemical Property of tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate

There total 1 articles about tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2R,4R)-2-phenyl-3,4-dihydro-2H-pyran-4-yl acetate (82740-79-2,116183-76-7,138512-07-9) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate (1208114-02-6)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 - 70 ℃;

DOI:10.1021/jo902167r

Reference yield: 76.0%

tert-butyldimethylsilyl 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)acetate (1208114-02-6) → 2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)ethanol (1208113-99-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 65 ℃; for 3h;

DOI:10.1021/jo902167r

upstream raw materials:

(2R,4R)-2-phenyl-3,4-dihydro-2H-pyran-4-yl acetate

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-((2R,6R)-6-phenyl-5,6-dihydro-2H-pyran-2-yl)ethanol