2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Base Information

Chemical Name:2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde
CAS No.:116006-20-3
Molecular Formula:C₉H₉BrO₃
Molecular Weight:245.073
Hs Code.:

Synonyms:2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Suppliers and Price of 2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

There total 14 articles about 2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2-bromo-6-methoxy-3-(2-methoxyvinyl)phenol

: 116006-20-3
2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 75 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/anie.201209868

Reference yield:

: 621-59-0
isovanillin

: 116006-20-3
2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / chloroform / Inert atmosphere; Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran / 0.42 h / -78 °C / Inert atmosphere

3.2: 3.58 h / 0 °C / Inert atmosphere; Reflux

4.1: toluene-4-sulfonic acid / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

5.1: tributylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 4 - 25 °C / Inert atmosphere

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate / toluene / 16 h / 110 °C / Inert atmosphere

6.2: 16 h / 0 - 25 °C / Inert atmosphere

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / N,N-dimethyl-formamide / 16 h / 0 - 25 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

9.1: water / acetonitrile / Inert atmosphere; Acidic conditions

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tributylphosphine; tri-tert-butyl phosphine; di-isopropyl azodicarboxylate; water; tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: Wittig reaction / 3.2: Wittig reaction / 5.1: Mitsunobu reaction / 6.1: Heck coupling reaction;
DOI:10.1139/v11-071

Reference yield:

: 1315614-02-8
tert-butyl 2-((5aS,9aS)-1-((1,3-dioxolan-2-yl)methyl)-4-methoxy-6-oxo-5a,6,9,9a-tetrahydrodibenzo[b,d]furan-9a-yl)ethyl(methyl)carbamate

: 116006-20-3
2-(2-bromo-3-hydroxy-4-methoxyphenyl)acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

2: water / acetonitrile / Inert atmosphere; Acidic conditions

With water; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1139/v11-071