4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

Base Information

Chemical Name:4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole
CAS No.:1448888-89-8
Molecular Formula:C₁₈H₁₆BrIO₄
Molecular Weight:503.131
Hs Code.:

Synonyms:4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

Chemical Property:

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Technology Process of 4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

There total 6 articles about 4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1448888-84-3
3-allyl-2-bromo-6-methoxyphenol

: 1448888-87-6
4-(bromomethyl)-5-iodobenzo[d][1,3]dioxole

: 1448888-89-8
4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201209868

Reference yield:

: 249636-72-4
5-iodobenzo[d][1,3]dioxole-4-carbaldehyde

: 1448888-89-8
4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 1 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; In ethanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201209868

Reference yield:

: 2-bromo-6-methoxy-3-(2-methoxyvinyl)phenol

: 1448888-89-8
4-((3-allyl-2-bromo-6-methoxyphenoxy)methyl)-5-iodobenzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 75 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 1 h / 80 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; water; acetonitrile; 2.2: |Wittig Olefination;
DOI:10.1002/anie.201209868