Technology Process of (S)-(+)-1-(3-methoxy-phenyl)-2-phenoxyethanol
There total 3 articles about (S)-(+)-1-(3-methoxy-phenyl)-2-phenoxyethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
(S)-(+)-2-(3-methoxyphenyl)oxirane;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 24h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/jo102294j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine; dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; water / 2 h
3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
3.2: 24 h / 60 °C / Inert atmosphere
With
2-[(1,3,2-dioxaborolan-2-yloxy)diphenylmethyl]pyrrolidine; dimethylsulfide borane complex; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo102294j
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / tetrahydrofuran; water / 2 h
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
2.2: 24 h / 60 °C / Inert atmosphere
With
sodium hydride; sodium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo102294j
