Rivaroxaban Impurity 12

Base Information

Chemical Name:Rivaroxaban Impurity 12
CAS No.:936232-22-3
Molecular Formula:C₁₇H₁₈ClN₃O₄S
Molecular Weight:395.867
Hs Code.:
Mol file:936232-22-3.mol

Synonyms:(S)-5-chloro-N-((3-(4-((2-hydroxyethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Suppliers and Price of Rivaroxaban Impurity 12

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-chloro-N-[[(5S)-3-[4-[(2-?hydroxyethyl)amino]phenyl]-2-oxo-5-oxazolidinyl]?methyl]?-2-thiophenecarboxamide?
25mg
$ 1320.00

TRC
5-chloro-N-[[(5S)-3-[4-[(2-?hydroxyethyl)amino]phenyl]-2-oxo-5-oxazolidinyl]?methyl]?-2-thiophenecarboxamide?
2.5mg
$ 165.00

Total 8 raw suppliers

Chemical Property of Rivaroxaban Impurity 12

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

5-chloro-N-[[(5S)-3-[4-[(2-?hydroxyethyl)amino]phenyl]-2-oxo-5-oxazolidinyl]?methyl]?-2-thiophenecarboxamide? ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5-chloro-N-[[(5S)-3-[4-[(2-?hydroxyethyl)amino]phenyl]-2-oxo-5-oxazolidinyl]?methyl]?-2-thiophenecarboxamide? is a metabolite of Rivaroxaban (R538000) which is a novel antithrombotic agent. Rivaroxaban is also a highly potent and selective, direct FXa inhibitor.

Technology Process of Rivaroxaban Impurity 12

There total 7 articles about Rivaroxaban Impurity 12 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 936232-12-1
N-[((5S)-3-{4-[(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)amino]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]-5-chlorothiophene-2-carboxamide

: 936232-22-3
(S)-5-chloro-N-((3-(4-((2-hydroxyethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 75-21-8,99932-75-9
oxirane

: 482308-02-1
N-{[(5S)-3-(4-aminophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chloro-2-thiophenecarboxamide

: 936232-22-3
(S)-5-chloro-N-((3-(4-((2-hydroxyethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: In ethanol; at 60 ℃; Solvent; Temperature;

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 936232-22-3
(S)-5-chloro-N-((3-(4-((2-hydroxyethyl)amino)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 50 °C

2: toluene / 0 - 15 °C

3: methylamine / ethanol; water / 40 °C

4: triethylamine / dichloromethane / 0 - 20 °C

5: hydrogen / methanol / 40 °C / Autoclave

6: ethanol / 60 °C

With hydrogen; triethylamine; methylamine; In methanol; ethanol; dichloromethane; water; toluene;