2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

Base Information

Chemical Name:2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide
CAS No.:1353004-55-3
Molecular Formula:C₂₁H₂₄IN₃O₅
Molecular Weight:525.343
Hs Code.:

Synonyms:2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

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Chemical Property of 2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

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Technology Process of 2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

There total 4 articles about 2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1360866-21-2
C₈H₇IO₄

: 392660-78-5
4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butan-1-amine

: 1353004-55-3
2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

Guidance literature:: C₈H₇IO₄; With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butan-1-amine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2011.10.046

Reference yield:

: 203505-66-2
7-nitro-2-(4-N-phthalimidobutyl)-1,2,3,4-tetrahydroisoquinoline

: 1353004-55-3
2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 1 h / Reflux

1.2: 4 h / Reflux

2.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.08 h / 20 °C

2.2: 20 °C

With hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2011.10.046

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1353004-55-3
2-hydroxy-4-iodo-3-methoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: P₂O₅/silica gel; nitric acid / water / 0.33 h / 20 °C

2.1: potassium carbonate / ethanol / 12 h / Reflux

3.1: hydrazine hydrate / ethanol / 1 h / Reflux

3.2: 4 h / Reflux

4.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.08 h / 20 °C

4.2: 20 °C

With P₂O₅/silica gel; nitric acid; potassium carbonate; hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2011.10.046