2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane

Base Information

• Chemical Name: 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane
• CAS No.: 1076206-57-9
• Molecular Formula: C₁₃H₁₅F₃N₂
• Molecular Weight: 256.271
• Mol file: 1076206-57-9.mol

Synonyms:2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane

Chemical Property of 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane

There total 5 articles about 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-diazabicyclo[2.2.2]octane (658-24-2) + 2,3,5-trifluorobenzaldehyde (126202-23-1) → 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane (1076206-57-9)

Guidance literature:

2,5-diazabicyclo[2.2.2]octane; 2,3,5-trifluorobenzaldehyde; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 1.5h;

Reference yield:

diethyl meso-2,5-dibromoadipate (54221-37-3) → 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane (1076206-57-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium azide

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 h / 750.08 Torr

3.1: methanol; sodium methylate

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Heating / reflux

4.2: 1 h / 20 °C

5.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 20 °C

5.2: 1.5 h / 20 °C

With hydrogenchloride; methanol; lithium aluminium tetrahydride; sodium azide; hydrogen; sodium methylate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane;

Reference yield:

(2R,5S)-2,5-diazidohexanedioic acid diethyl ester (54221-38-4) → 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane (1076206-57-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 h / 750.08 Torr

2.1: methanol; sodium methylate

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Heating / reflux

3.2: 1 h / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

With hydrogenchloride; methanol; lithium aluminium tetrahydride; hydrogen; sodium methylate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane;

upstream raw materials:

2,5-diazabicyclo[2.2.2]octane

2,3,5-trifluorobenzaldehyde

diethyl meso-2,5-dibromoadipate

(2R,5S)-2,5-diazidohexanedioic acid diethyl ester