pleuromutilin tosylate

Base Information

• Chemical Name: pleuromutilin tosylate
• CAS No.: 31716-01-5
• Molecular Formula: C₂₉H₄₀O₇S
• Molecular Weight: 532.698
• Hs Code.: 2941906000
• Mol file: 31716-01-5.mol

Synonyms:pleuromutilin tosylate

Chemical Property of pleuromutilin tosylate

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Tiamulin Related Compound A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 22-O-Tosylpleuromutilin is a pleuromutilin derivative that exhibits antibacterial activities against Staphyllococcus aureus.

Technology Process of pleuromutilin tosylate

There total 6 articles about pleuromutilin tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

p-toluenesulfonyl chloride (98-59-9) + pleuromutilin → pleuromutilin tosylate (31716-01-5)

Guidance literature:

With triethylamine; In dichloromethane; at 30 ℃; for 4h; Temperature;

Reference yield: 56.3%

pleuromutilin + p-toluenesulfonyl chloride (98-59-9) → Pleuromutilin-22-O-tosylat (31716-01-5,110043-77-1)

Guidance literature:

With pyridine; at 0 ℃; for 3h;

DOI:10.4067/S0717-97072013000100008

Reference yield: 39.4%

Pleuromutilin-22-O-tosylat (31716-01-5,110043-77-1) → 22-O-Tosyl-12-epi-pleuromutilin (31716-01-5,110043-77-1)

Guidance literature:

With ethylzinc iodide; In diethyl ether; N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1007/BF00811277

upstream raw materials:

p-toluenesulfonyl chloride

diiodomethane

Pleuromutilin-22-O-tosylat

toluene-4-sulfonic acid

Downstream raw materials:

tiamutin

[2-(2-Diethylamino-ethoxy)-phenylsulfanyl]-acetic acid 3-hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyl-tricyclo[5.4.3.0^1,8]tetradec-6-yl ester

12-Desvinyl-12-cyclopropyl-22-O-tosyl-pleuromutilin

22-O-Tosyl-12-epi-pleuromutilin