2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

Base Information

Chemical Name:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate
CAS No.:1443053-14-2
Molecular Formula:C₂₁H₂₄N₂O₈
Molecular Weight:432.43
Hs Code.:

Synonyms:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

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Chemical Property of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

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Technology Process of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

There total 11 articles about 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1443052-79-6
ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 108-24-7
acetic anhydride

: 1443053-14-2
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

Guidance literature:: With sodium acetate; at 100 ℃; for 2h;

Reference yield:

: 98269-30-8
diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

: 1443053-14-2
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium ethanolate / ethanol / 1 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3: sodium hydroxide; water / tetrahydrofuran; ethanol / 16 h / 50 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C / Inert atmosphere

6: sodium acetate / 2 h / 100 °C

With palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1443053-94-8
triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 1443053-14-2
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl diacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C / Inert atmosphere

3: sodium acetate / 2 h / 100 °C

With palladium 10% on activated carbon; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide;