4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

Base Information

Chemical Name:4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol
CAS No.:1224948-72-4
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

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Chemical Property of 4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

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Technology Process of 4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

There total 11 articles about 4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1224950-11-1
4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

: 1224948-73-5
4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-1-cyclohexanol

: 1224948-72-4
4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

Guidance literature:: 4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one; With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

: C₃₁H₃₄N₂O₃

: 1224948-73-5
4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-1-cyclohexanol

: 1224948-72-4
4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1224948-73-5
4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-1-cyclohexanol

: 1224948-72-4
4-(hydroxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-trans-1-cyclohexanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.33 h / -78 °C

1.2: 2 h / -78 - 20 °C

1.3: 4 h

2.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice

3.1: triethylamine; pyridine-SO₃ complex / dimethyl sulfoxide / 0.33 h / 20 °C

4.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

5.2: 1 h / -78 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 13 h / 20 °C

7.1: triethylamine / ethanol / 0.5 h / 20 °C

7.2: 15 h / 20 °C

8.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

8.2: 0 °C

9.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

10.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

With hydrogenchloride; methanol; manganese(IV) oxide; sodium tetrahydroborate; lithium borohydride; n-butyllithium; pyridine-SO₃ complex; water; hydrogen; potassium hexamethylsilazane; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene;