4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

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Chemical Name:4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one
CAS No.:1224950-11-1
Molecular Formula:C₃₁H₃₂N₂O₃
Molecular Weight:480.607
Hs Code.:

Synonyms:4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

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Chemical Property of 4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

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Technology Process of 4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

There total 9 articles about 4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1224950-10-0
3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

: 1224950-11-1
4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

Guidance literature:: 3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 15h;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1224950-11-1
4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.33 h / -78 °C

1.2: 2 h / -78 - 20 °C

1.3: 4 h

2.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice

3.1: triethylamine; pyridine-SO₃ complex / dimethyl sulfoxide / 0.33 h / 20 °C

4.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

5.2: 1 h / -78 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 13 h / 20 °C

7.1: triethylamine / ethanol / 0.5 h / 20 °C

7.2: 15 h / 20 °C

8.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

8.2: 0 °C

With hydrogenchloride; manganese(IV) oxide; lithium borohydride; n-butyllithium; pyridine-SO₃ complex; water; potassium hexamethylsilazane; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1224950-04-2
ethyl 8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-carboxylate

: 1224950-11-1
4-(benzyloxymethyl)-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice

2.1: triethylamine; pyridine-SO₃ complex / dimethyl sulfoxide / 0.33 h / 20 °C

3.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

4.2: 1 h / -78 - 20 °C

5.1: manganese(IV) oxide / dichloromethane / 13 h / 20 °C

6.1: triethylamine / ethanol / 0.5 h / 20 °C

6.2: 15 h / 20 °C

7.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

7.2: 0 °C

With hydrogenchloride; manganese(IV) oxide; lithium borohydride; n-butyllithium; pyridine-SO₃ complex; water; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide;