1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid
CAS No.:1242456-23-0
Molecular Formula:C₃₂H₃₇N₃O₄
Molecular Weight:527.663
Hs Code.:

Synonyms:1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

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Chemical Property of 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

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Technology Process of 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

There total 5 articles about 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1242457-11-9
tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

: 1242456-23-0
1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1242456-38-7
tert-butyl 1-(4-azidobutyl)cyclopropanecarboxylate

: 1242456-23-0
1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 738606-85-4
t-butyl 1-(4-bromobutyl)-1-cyclopropanecarboxylate

: 1242456-23-0
1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)amino]butyl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

2: ethanol; hydrazine hydrate / 0.75 h / Reflux

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With ethanol; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;