tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

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Chemical Name:tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate
CAS No.:1242457-11-9
Molecular Formula:C₃₆H₄₅N₃O₄
Molecular Weight:583.771
Hs Code.:

Synonyms:tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

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Chemical Property of tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

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Technology Process of tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

There total 5 articles about tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242456-54-7
tert-butyl 1-(4-aminobutyl)cyclopropanecarboxylate

: 1192042-17-3
cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetic acid

: 1242457-11-9
tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1242456-38-7
tert-butyl 1-(4-azidobutyl)cyclopropanecarboxylate

: 1242457-11-9
tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In N,N-dimethyl-formamide;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1242457-11-9
tert-butyl 1-{4-[(cyclopentyl{4-[(6-oxo-3-phenylpyridazin-1(6H)-yl)methyl]phenyl}acetyl)-amino]butyl}cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 5 h / -78 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: ethanol; hydrazine hydrate / 0.75 h / Reflux

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With n-butyllithium; ethanol; potassium carbonate; hydrazine hydrate; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;