6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

Base Information

Chemical Name:6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione
CAS No.:1468402-97-2
Molecular Formula:C₂₂H₁₁F₂NO₃
Molecular Weight:375.331
Hs Code.:

Synonyms:6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

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Chemical Property of 6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

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Technology Process of 6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

There total 4 articles about 6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1468402-85-8
N-(3-ethynylphenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

: 79-22-1
methyl chloroformate

: 1468402-97-2
6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 13h; Reflux;

Reference yield:

: 22494-42-4
2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

: 1468402-97-2
6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / tetrahydrofuran / 6 h / Reflux; Inert atmosphere; Dean-Stark

2: tetrahydrofuran / Reflux

3: pyridine / tetrahydrofuran / 14 h / 0 - 70 °C

With pyridine; thionyl chloride; In tetrahydrofuran;
DOI:10.1016/j.bmc.2015.06.007

Reference yield:

: 344348-56-7
C₁₃H₇ClF₂O₂

: 1468402-97-2
6-(2,4-difluorophenyl)-3-(3-ethynylphenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / Reflux

2: pyridine / tetrahydrofuran / 14 h / 0 - 70 °C

With pyridine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2015.06.007