(S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

Base Information

Chemical Name:(S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide
CAS No.:1039736-64-5
Molecular Formula:C₂₃H₁₉Cl₂N₅O
Molecular Weight:452.343
Hs Code.:

Synonyms:(S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

Suppliers and Price of (S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

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Technology Process of (S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

There total 4 articles about (S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 25171-19-1
7-methyl-2,4-dichloroquinazoline

: 1039736-63-4
(S)-N-(4-(1-aminoethyl)phenyl)-6-chloronicotinamide

: 1039736-64-5
(S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 255060-77-6
(S)-[1-(4-aminophenyl)ethyl]carbamic acid tert-butyl ester

: 1039736-64-5
(S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 177947-88-5
(S)-tert-butyl 1-(4-nitrophenyl)ethylcarbamate

: 1039736-64-5
(S)-6-chloro-N-(4-(1-(2-chloro-7-methylquinazolin-4-ylamino)ethyl)phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: iron; ammonium chloride / ethanol; water / Heating / reflux

2: triethylamine / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 20 °C

With iron; ammonium chloride; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;