2,4-DICHLORO-1,2,3,4-TETRAHYDRO-7-METHYLQUINAZOLINE

Base Information

• Chemical Name: 2,4-DICHLORO-1,2,3,4-TETRAHYDRO-7-METHYLQUINAZOLINE
• CAS No.: 25171-19-1
• Molecular Formula: C9H6Cl2N2
• Molecular Weight: 213.066
• Hs Code.: 2933990090
• Mol file: 25171-19-1.mol

Synonyms:7-methyl-2,4-dichloroquinazoline;2,4-Dichlor-7-methyl-chinazolin;7-Methyl-2,4-dichlor-chinazolin;Quinazoline,2,4-dichloro-7-methyl;

Chemical Property of 2,4-DICHLORO-1,2,3,4-TETRAHYDRO-7-METHYLQUINAZOLINE

Chemical Property:

• Vapor Pressure: 0.121mmHg at 25°C
• Boiling Point: 226.8oC at 760 mmHg
• PKA: -0.15±0.30(Predicted)
• Flash Point: 112.678oC
• PSA: 24.06000
• Density: 1.419g/cm3
• LogP: 3.23670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,4-dichloro-7-methylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DICHLORO-1,2,3,4-TETRAHYDRO-7-METHYLQUINAZOLINE

There total 6 articles about 2,4-DICHLORO-1,2,3,4-TETRAHYDRO-7-METHYLQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-methylquinazoline-2,4-(1H,3H)-dione (62484-15-5) → 7-methyl-2,4-dichloroquinazoline (25171-19-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; for 3h; Reflux;

DOI:10.1016/j.bmcl.2011.10.104

Reference yield:

4-methylanthranilic acid (2305-36-4) → 7-methyl-2,4-dichloroquinazoline (25171-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous hydrochloric acid

2: aqueous HCl

3: POCl₃; PCl₅

With hydrogenchloride; phosphorus pentachloride; trichlorophosphate;

Reference yield:

2-amino-4-methylbenzamide (39549-79-6) → 7-methyl-2,4-dichloroquinazoline (25171-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous acetic acid

2: aqueous HCl

3: POCl₃; PCl₅

With hydrogenchloride; phosphorus pentachloride; acetic acid; trichlorophosphate;

upstream raw materials:

7-methylquinazoline-2,4-(1H,3H)-dione

2-amino-4-methylbenzamide

4-methylanthranilic acid

Downstream raw materials:

(2-N-methylamino-7-methylquinazolin-4-yl)(4-nitrobenzyl)amine

4-bromo-N-[4-({[7-methyl-2-(methylamino)quinazolin-4-yl]amino}methyl)phenyl]benzamide

tert-butyl 4-({[4-((1S)-1-{[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}ethyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

Refernces

• 1、 -. "N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof". Page/Page column 47; 50. . Retrieved 2019/07/03.
• 2、 -. "AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS". Paragraph 00430; 00431. . Retrieved 2017/05/19.