Technology Process of 3-Cyano-1-methylenecyclohexane-2,2,4,4,6,6-d6
There total 5 articles about 3-Cyano-1-methylenecyclohexane-2,2,4,4,6,6-d6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phenyllithium;
In
diethyl ether; hexane;
for 15h;
Ambient temperature;
DOI:10.1021/jo01291a015
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 47 percent / pentane; toluene; pyridine / 1) 0 deg C, 1 h; 2.) room temperature, 1 h
2: 83 percent / acetic acid-d/D2O / 1 h / Ambient temperature
3: 80 percent / C6H5Li / diethyl ether; hexane / 15 h / Ambient temperature
With
acetic acid-d; water-d2; phenyllithium;
In
pyridine; diethyl ether; hexane; toluene; pentane;
DOI:10.1021/jo01291a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / 1.)MeONa, 2.) 15N DCl/D2O / 24 h / Ambient temperature
2: 73 percent / 1.) LiAlH4, 2.) 15N DCl/D2O / diethyl ether / 1 h / Heating
3: 47 percent / pentane; toluene; pyridine / 1) 0 deg C, 1 h; 2.) room temperature, 1 h
4: 83 percent / acetic acid-d/D2O / 1 h / Ambient temperature
5: 80 percent / C6H5Li / diethyl ether; hexane / 15 h / Ambient temperature
With
lithium aluminium tetrahydride; diclazuril; acetic acid-d; water-d2; sodium methylate; phenyllithium;
In
pyridine; diethyl ether; hexane; toluene; pentane;
DOI:10.1021/jo01291a015
