trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

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Chemical Name:trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol
CAS No.:1350324-96-7
Molecular Formula:C₂₆H₂₈ClFN₄O₃
Molecular Weight:498.985
Hs Code.:

Synonyms:trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

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Chemical Property of trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

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Technology Process of trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

There total 12 articles about trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₄₂ClFN₄O₃Si

: 1350324-96-7
trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: C₃₂H₄₂ClFN₄O₃Si; With hydrogenchloride; water; In 1,4-dioxane; at 60 ℃; for 0.25h; microwave irradiation; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; chloroform; water;

Reference yield:

: 23511-05-9
toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

: 1350324-96-7
trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 19 h / 100 °C

2.1: water; pyridinium p-toluenesulfonate / acetone / 23 h / 60 °C

3.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

4.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

5.1: potassium carbonate; potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1.17 h / 100 °C / Inert atmosphere; microwave irradiation

5.2: 0.5 h / 100 °C / microwave irradiation; Inert atmosphere

6.1: hydrogenchloride; water / 1,4-dioxane / 0.25 h / 60 °C / microwave irradiation; Inert atmosphere

With 1H-imidazole; hydrogenchloride; dmap; potassium fluoride; sodium tetrahydroborate; ethanol; water; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1350325-03-9
trans-4-(4-iodo-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

: 1350324-96-7
trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3-methoxy-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

2.1: potassium carbonate; potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1.17 h / 100 °C / Inert atmosphere; microwave irradiation

2.2: 0.5 h / 100 °C / microwave irradiation; Inert atmosphere

3.1: hydrogenchloride; water / 1,4-dioxane / 0.25 h / 60 °C / microwave irradiation; Inert atmosphere

With 1H-imidazole; hydrogenchloride; dmap; potassium fluoride; water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water;