1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate

Base Information

• Chemical Name: 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate
• CAS No.: 23511-05-9
• Molecular Formula: C15H20O5S
• Molecular Weight: 312.387
• Hs Code.: 2932999099
• Mol file: 23511-05-9.mol

Synonyms:1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate;1,4-Dioxaspiro[4.5]decan-8-yl 4-Methylbenzenesulfonate

Chemical Property of 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate

Chemical Property:

• PSA: 70.21000
• LogP: 3.46680

Purity/Quality:

99% ^*data from raw suppliers

1,4-Dioxaspiro[4.5]decan-8-yl4-methylbenzenesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate

There total 4 articles about 1,4-Dioxaspiro[4.5]decan-8-ol 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4-ethylenedioxycyclohexan-1-ol (22428-87-1) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester (23511-05-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

4,4-ethylenedioxycyclohexan-1-ol (22428-87-1) + toluene-4-sulfonic acid (104-15-4) → toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester (23511-05-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester (23511-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 2 h / 0 °C

2: 9.67 g / pyridine / 18 h / 20 °C

With pyridine; sodium tetrahydroborate; In methanol;

DOI:10.1039/b206705f

upstream raw materials:

4,4-ethylenedioxycyclohexan-1-ol

p-toluenesulfonyl chloride

cyclohexanedione monoethylene ketal

toluene-4-sulfonic acid

Downstream raw materials:

4-(1H-pyrazol-1-yl)cyclohexan-1-one

trans-4-[4-(3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

trans-4-[4-(3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

5-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-1H-pyrazol-4-yl]-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoro-2,2-bis(phenylsulfonyl)ethyl}-1H-pyrrolo[2,3-b]pyridine

Refernces

• 1、 -. "COMPOUND SERVING AS IRAK INHIBITOR". Paragraph 0296; 0302; 0329-0330. . Retrieved 2021/10/07.
• 2、 -. "AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF". Page/Page column 141-142. . Retrieved 2021/02/26.