4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

Base Information

Chemical Name:4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid
CAS No.:1620722-97-5
Molecular Formula:C₁₈H₁₃Cl₂F₃N₂O₂
Molecular Weight:417.215
Hs Code.:

Synonyms:4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

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Chemical Property of 4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

Chemical Property:

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Technology Process of 4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

There total 6 articles about 4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620722-96-4
tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

: 1620722-97-5
4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 5 ℃; for 6h;

Reference yield:

: 1620722-94-2
1,3-dichloro-5-[2,2,2-trifluoro-1,1-bis(nitromethyl)ethyl]benzene

: 1620722-97-5
4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; acetic acid / methanol / 1 h / Reflux

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 12 h / 80 °C / High pressure; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 6 h / 0 - 5 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; trifluoroacetic acid; sodium t-butanolate; zinc; In methanol; dichloromethane; toluene; 2: |Buchwald-Hartwig Coupling;

Reference yield:

: 933451-84-4
2-(3,5-dichlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-ol

: 1620722-97-5
4-[4-(3,5-dichlorophenyl)-4-(trfluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride; pyridine / toluene / 3 h / 0 - 20 °C

2: sodium ethanolate / ethanol / 20 °C

3: zinc; acetic acid / methanol / 1 h / Reflux

4: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 12 h / 80 °C / High pressure; Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 6 h / 0 - 5 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; sodium ethanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; trifluoroacetic acid; sodium t-butanolate; zinc; In methanol; ethanol; dichloromethane; toluene; 4: |Buchwald-Hartwig Coupling;