tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

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Chemical Name:tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate
CAS No.:1620722-96-4
Molecular Formula:C₂₂H₂₁Cl₂F₃N₂O₂
Molecular Weight:473.322
Hs Code.:

Synonyms:tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

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Chemical Property of tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

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Technology Process of tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

There total 5 articles about tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 445003-37-2
4-bromo-2-methyl-benzoic acid tert-butyl ester

: 1620722-95-3
4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-1,5-dihydropyrazole

: 1620722-96-4
tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 80 ℃; for 12h; High pressure; Inert atmosphere;

Reference yield:

: 1620722-94-2
1,3-dichloro-5-[2,2,2-trifluoro-1,1-bis(nitromethyl)ethyl]benzene

: 1620722-96-4
tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / methanol / 1 h / Reflux

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 12 h / 80 °C / High pressure; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium t-butanolate; zinc; In methanol; toluene; 2: |Buchwald-Hartwig Coupling;

Reference yield:

: 1620722-93-1
1,3-dichloro-5-[(Z)-2-nitro-1-(trifluoromethyl)vinyl]benzene

: 1620722-96-4
tert-butyl 4-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3H-pyrazol-2-yl]-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / 20 °C

2: zinc; acetic acid / methanol / 1 h / Reflux

3: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 12 h / 80 °C / High pressure; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium ethanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium t-butanolate; zinc; In methanol; ethanol; toluene; 3: |Buchwald-Hartwig Coupling;