2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine

Base Information

• Chemical Name: 2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine
• CAS No.: 332134-76-6
• Molecular Formula: C₁₈H₂₀FIN₂O₂
• Molecular Weight: 442.272

Synonyms:2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine

Chemical Property of 2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine

Chemical Property:

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Technology Process of 2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine

There total 1 articles about 2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]pyridine → 2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine (332134-76-6)

Guidance literature:

With N-iodo-succinimide; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine (332134-76-6) + (R)-(+)-3-ethynyl-3-hydroxy quinuclidine (160172-20-3) → (3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol (332132-48-6)

Guidance literature:

With copper(I) iodide; triethylamine; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In methanol; N,N-dimethyl-formamide;

Downstream raw materials:

(3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

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