(3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

Base Information

Chemical Name:(3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol
CAS No.:332132-48-6
Molecular Formula:C₂₇H₃₂FN₃O₃
Molecular Weight:465.568
Hs Code.:

Synonyms:(3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

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Chemical Property of (3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

Chemical Property:

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Technology Process of (3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

There total 2 articles about (3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 332134-76-6
2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-3-iodopyridine

: 160172-20-3
(R)-(+)-3-ethynyl-3-hydroxy quinuclidine

: 332132-48-6
(3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

Guidance literature:: With copper(I) iodide; triethylamine; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 2-benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]pyridine

: 332132-48-6
(3R)-3-[2-Benzyl-6-[(3R,4S)-3-(fluoromethoxy)-4-methoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / water; ethyl acetate; N,N-dimethyl-formamide

2: copper(I) iodide; triethylamine / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / methanol; N,N-dimethyl-formamide

With N-iodo-succinimide; copper(I) iodide; triethylamine; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;