methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

Base Information

Chemical Name:methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate
CAS No.:1610967-52-6
Molecular Formula:C₁₇H₁₀IN₃O₄
Molecular Weight:447.189
Hs Code.:

Synonyms:methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

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Chemical Property of methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

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Technology Process of methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

There total 2 articles about methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 304-91-6
2-iodoxybenzoic acid

: 1610967-47-9
methyl 3-Azido-4-[(trimethylsilyl)ethynyl]benzoate

: 1610967-52-6
methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

Guidance literature:: 2-iodoxybenzoic acid; methyl 3-Azido-4-[(trimethylsilyl)ethynyl]benzoate; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

With pyridine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol5012604

Reference yield:

: 1186611-25-5
methyl 3-amino-4-[(trimethylsilyl)ethynyl]benzoate

: 1610967-52-6
methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; sodium nitrite / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; trifluoroacetic acid; sodium nitrite; In water; acetonitrile; 1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction;
DOI:10.1021/ol5012604