methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

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Chemical Name:methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate
CAS No.:1610967-18-4
Molecular Formula:C₂₉H₃₀N₄O₄SSi
Molecular Weight:558.733
Hs Code.:

Synonyms:methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

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Chemical Property of methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

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Technology Process of methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

There total 7 articles about methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1610967-52-6
methyl 3-azido-4-[(3-oxo-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)ethynyl]benzoate

: 1610967-57-1
(Z)-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

: 1610967-18-4
methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

Guidance literature:: With potassium phosphate; copper(l) iodide; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1021/ol5012604

Reference yield:

: 1610967-47-9
methyl 3-Azido-4-[(trimethylsilyl)ethynyl]benzoate

: 1610967-18-4
methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

With potassium phosphate; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol5012604

Reference yield:

: 1186611-25-5
methyl 3-amino-4-[(trimethylsilyl)ethynyl]benzoate

: 1610967-18-4
methyl (Z)-3-Azido-4-{[(4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}phenyl)sulfonamido]ethynyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; sodium nitrite / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

With potassium phosphate; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; water; acetonitrile; 1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction;
DOI:10.1021/ol5012604