tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate

Base Information

• Chemical Name: tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate
• CAS No.: 252931-41-2
• Molecular Formula: C₄₁H₄₆O₁₄P₂
• Molecular Weight: 824.755
• Mol file: 252931-41-2.mol

Synonyms:tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate

Chemical Property of tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate

There total 1 articles about tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

P,P'-methanediyl-bis-phosphonic acid tetrachloride (1499-29-2) + 3-hydroxypropyl benzoate (6946-99-2) → tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate (252931-41-2)

Guidance literature:

With pyridine; In toluene; at 0 - 20 ℃;

DOI:10.1021/jm991109o

Reference yield: 90.0%

tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate (252931-41-2) → C41H44Cl2O14P2 (252931-42-3)

Guidance literature:

With sodium hypochlorite; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate;

DOI:10.1021/jm991109o

Reference yield:

tetrakis[3-(phenylmethanoyloxy)propyl] methylenebisphosphonate (252931-41-2) → C21H24Cl2O10P2*2C5H11N

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. NaOCl; NaHCO₃; benzyltriethylammonium chloride

2: 40 percent / 0.5 h / 120 °C

With sodium hypochlorite; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; 1: Chlorination / 2: Substitution;

DOI:10.1021/jm991109o

upstream raw materials:

P,P'-methanediyl-bis-phosphonic acid tetrachloride

3-hydroxypropyl benzoate

Downstream raw materials:

C₄₁H₄₄Cl₂O₁₄P₂