22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate

Base Information

• Chemical Name: 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate
• CAS No.: 133910-23-3
• Molecular Formula: C₂₆H₃₉F₃O₄SSi
• Molecular Weight: 532.74

Synonyms:22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate

Chemical Property of 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate

There total 6 articles about 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-Iodophenol (540-38-5) → 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate (133910-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 94 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

4: 1.) LDA / 1.) THF, hexane, -30 deg C, 4 h, 2.) THF, hexane, 0 deg C, 15 h

With 1H-imidazole; dipyridinium dichromate; pyridinium trifluroacetate; lithium diisopropyl amide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00112a021

Reference yield:

(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate (66774-80-9,111924-49-3) → 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate (133910-23-3)

Guidance literature:

Multi-step reaction with 3 steps

2: 94 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

3: 1.) LDA / 1.) THF, hexane, -30 deg C, 4 h, 2.) THF, hexane, 0 deg C, 15 h

With dipyridinium dichromate; pyridinium trifluroacetate; lithium diisopropyl amide; In dichloromethane;

DOI:10.1021/jm00112a021

Reference yield:

22-phenyl>-de-A,B-24-norcholan-8β-ol (133910-15-3) → 22-phenyl>-de-A,B-24-norchol-8-enyl trifluoromethanesulfonate (133910-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

2: 1.) LDA / 1.) THF, hexane, -30 deg C, 4 h, 2.) THF, hexane, 0 deg C, 15 h

With dipyridinium dichromate; pyridinium trifluroacetate; lithium diisopropyl amide; In dichloromethane;

DOI:10.1021/jm00112a021

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

22-phenyl>-de-A,B-24-norcholan-8-one

p-Iodophenol

(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

Downstream raw materials:

1α,3β-bis<(tert-butyldimethylsilyl)oxy>-22-phenyl>-24-nor-9,10-secochola-5(10),8-dien-6-yne

22-(p-hydroxyphenyl)-23,24,25,26,27-pentanor-1α-hydroxyvitamin D₃

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