3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

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Chemical Name:3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine
CAS No.:401567-01-9
Molecular Formula:C₂₈H₃₁N₇O₃S
Molecular Weight:545.665
Hs Code.:

Synonyms:3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

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Chemical Property of 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

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Technology Process of 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

There total 6 articles about 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 401567-00-8
2-chlorobenzimidazole-5-carbonitrile

: 401566-48-1
3-[(2S,4S)-1-benzyloxycarbonyl-4-(piperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

: 401567-01-9
3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃;
DOI:10.1016/j.bmc.2012.06.033

Reference yield:

: 401566-46-9
3-((S)-1-benzyloxycarbonyl-4-oxopyrrolidin-2-ylcarbonyl)thiazolidine

: 401567-01-9
3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 100 °C

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2012.06.033

Reference yield:

: 401566-47-0
3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

: 401567-01-9
3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-cyanobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 100 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/j.bmc.2012.06.033