3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

Base Information

Chemical Name:3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine
CAS No.:401566-47-0
Molecular Formula:C₂₅H₃₆N₄O₅S
Molecular Weight:504.651
Hs Code.:

Synonyms:3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

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Chemical Property of 3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

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Technology Process of 3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

There total 3 articles about 3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 401566-46-9
3-((S)-1-benzyloxycarbonyl-4-oxopyrrolidin-2-ylcarbonyl)thiazolidine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 401566-47-0
3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

Guidance literature:: 3-((S)-1-benzyloxycarbonyl-4-oxopyrrolidin-2-ylcarbonyl)thiazolidine; 1-t-Butoxycarbonylpiperazine; With sodium cyanoborohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2012.06.033

Reference yield:

: 197079-48-4
trans-N-(Benzyloxycarbonyl)-4-hydroxy-L-proline

: 401566-47-0
3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide

3: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With sulfur trioxide pyridine complex; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.033

Reference yield:

: C₁₆H₂₀N₂O₄S

: 401566-47-0
3-[(2S,4S)-1-benzyloxycarbonyl-4-(4-tert-butoxycarbonylpiperazin-1-yl)pyrrolidin-2-ylcarbonyl]thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide

2: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With sulfur trioxide pyridine complex; sodium cyanoborohydride; acetic acid; triethylamine; In dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2012.06.033