ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate

Base Information

• Chemical Name: ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate
• CAS No.: 146560-57-8
• Molecular Formula: C₁₉H₁₇Cl₂FN₂O₄
• Molecular Weight: 427.259
• Mol file: 146560-57-8.mol

Synonyms:ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate

Chemical Property of ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate

There total 1 articles about ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-aniline (104-94-9) + 2-(ethoxymethylene)-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxopropionic acid ethyl ester (132195-45-0) → ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate (146560-57-8)

Guidance literature:

In ethanol; for 2h; Ambient temperature;

DOI:10.3987/COM-92-6121

Reference yield: 82.0%

ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate (146560-57-8) → 7-Chloro-6-fluoro-1-(4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester (146560-53-4)

Guidance literature:

With potassium carbonate; In acetonitrile; for 2h;

DOI:10.3987/COM-92-6121

Reference yield:

ethyl 2-<((4-methoxyphenyl)amino)-methylene>-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxo-propionate (146560-57-8) → 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester (146560-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / acetonitrile / 2 h

2: 98 percent / DBU / acetonitrile / Ambient temperature

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.3987/COM-92-6121

upstream raw materials:

4-methoxy-aniline

2-(ethoxymethylene)-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxopropionic acid ethyl ester

Downstream raw materials:

7-Chloro-6-fluoro-1-(4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester