25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

Base Information

Chemical Name:25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene
CAS No.:299411-91-9
Molecular Formula:C₆₆H₈₄O₁₂S₂
Molecular Weight:1133.52
Hs Code.:

Synonyms:25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

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Chemical Property of 25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

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Technology Process of 25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

There total 3 articles about 25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 98-59-9
p-toluenesulfonyl chloride

: 299411-90-8
25,27-bis(2-hydroxyethoxy)ethoxy-26,28-dihydroxy-5,11,17,23-tetra(tert-butyl)calix[4]arene

: 299411-91-9
25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

Guidance literature:: With pyridine; In dichloromethane; chloroform; at 20 ℃; for 72h;
DOI:10.1021/jo000196l

Reference yield: 50.0%

: 157432-87-6,288302-11-4,288302-12-5,60705-62-6
5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

: 118591-58-5
5-tosyloxy-3-oxapentanol

: 299411-91-9
25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; for 2h; Heating;
DOI:10.1016/j.tet.2004.04.020

Reference yield:

: 157432-87-6,288302-11-4,288302-12-5,60705-62-6
5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

: 299411-91-9
25,27-bis(1-p-toluenesulfonyloxy-3-oxapent-5-yl)oxy-26,28-dihydroxy-5,11,17,23-tetra-tert-butyl-calix[4]arene

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / K₂CO₃ / acetonitrile / 144 h / Heating

2: 71 percent / pyridine / CH₂Cl₂; CHCl₃ / 72 h / 20 °C

With pyridine; potassium carbonate; In dichloromethane; chloroform; acetonitrile; 1: Alkylation / 2: Tosylation;
DOI:10.1021/jo000196l