Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate)

Base Information

• Chemical Name: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate)
• CAS No.: 118591-58-5
• Molecular Formula: C11H16O5S
• Molecular Weight: 260.311
• Hs Code.: 2909499000
• Mol file: 118591-58-5.mol

Synonyms:2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate;Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate);Ts(OCH2CH2)2OH;2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol;2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate;toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester;diethylene glycol mono-p-toluenesulfonate;

Chemical Property of Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate)

Chemical Property:

• Boiling Point: 427.4±30.0 °C(Predicted)
• PKA: 14.32±0.10(Predicted)
• PSA: 81.21000
• Density: 1.256±0.06 g/cm3(Predicted)
• LogP: 1.79000
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate)

There total 8 articles about Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-toluenesulfonyl chloride (98-59-9) + diethylene glycol (111-46-6) → 5-tosyloxy-3-oxapentanol (118591-58-5)

Guidance literature:

With potassium iodide; silver(l) oxide; In dichloromethane; for 10h;

Reference yield: 92.0%

p-toluenesulfonyl chloride (98-59-9) + diethylene glycol (111-46-6) → 5-tosyloxy-3-oxapentanol (118591-58-5) + diethylene glycol ditosylate (7460-82-4)

Guidance literature:

With potassium iodide; silver(l) oxide; In dichloromethane; at 0 ℃; for 0.0833333h;

DOI:10.1021/ol020071y

Reference yield: 61.0%

→ 5-tosyloxy-3-oxapentanol (118591-58-5)

Guidance literature:

With potassium iodide; silver(l) oxide; In dichloromethane; at 0 - 20 ℃; for 16h;

upstream raw materials:

p-toluenesulfonyl chloride

diethylene glycol

2-(2-methoxyethoxy)ethyl alcohol

diethylene glycol ditosylate

Downstream raw materials:

2-(2-(4-bromophenoxy)ethoxy)ethanol

3,4-bis-[2-(2-hydroxy-ethoxy)-ethoxy]-benzaldehyde

2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethyl 4-methylbenzenesulfonate

1-<2-(2-hydroxyethoxy)ethoxy>-4-benzyloxybenzene

Refernces

• 1、 Song, Rita,Kim, Yeong-Sang,Lee, Chong Ock,Sohn, Youn Soo. "Synthesis and antitumor activity of DNA binding cationic porphyrin-platinum(II) complexes". . p. 1537 - 1540. Retrieved 2003.
• 2、 Wu, Xuan,Gao, Lei,Sun, Junzhao,Hu, Xiao-Yu,Wang, Leyong. "Stable pillar[5]arene-based pseudo[1]rotaxanes formed in polar solution". . p. 1655 - 1660. Retrieved 2016.
• 3、 Abdmouleh, Fatma,Ali, Mamdouh Ben,Arbi, Mehdi El,Ferroud, Clotilde,Goya-Jorge, Elizabeth,Guenineche, Léna,Lagarde, Nathalie,Liagre, Bertrand,Martin, Frédérique,Ricco, Christophe,Riccobono, Charlotte,Veitía, Maité Sylla-Iyarreta. "Pegylated triarylmethanes: Synthesis, antimicrobial activity, anti-proliferative behavior and in silico studies". . . Retrieved 2020.
• 4、 Zhang, Fangqing,Wu, Zhenwei,Chen, Pan,Zhang, Jian,Wang, Tao,Zhou, Jinpei,Zhang, Huibin. "Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide". . . Retrieved 2020.
• 5、 Hao, Xiangnan,Mu, Bin,Tian, Wei,Zhang, Zhelin,Zhao, Yu. "Fluorescent Columnar Liquid-Crystalline Polymers: Synthesis, Mesomorphic Behaviors and Tunable Emission Wavelengths?". supporting information. p. 2009 - 2015. Retrieved 2021/06/08.
• 6、 -. "Supramolecular compound nano-carrier as well as preparation method and application thereof". Paragraph 0068; 0082. . Retrieved 2021/08/14.