(2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

Base Information

Chemical Name:(2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide
CAS No.:93591-44-7
Molecular Formula:C₂₆H₄₂BrNO₈Si
Molecular Weight:604.611
Hs Code.:

(2S,3R)-N-(2,4-dimethoxybenzyl)-N-<bis(ethoxycarbonyl)methyl>-2-bromo-3-(t-butyldimethylsilyloxy)butyramide

Synonyms:(2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

Suppliers and Price of (2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

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Technology Process of (2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

There total 2 articles about (2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 81902-49-0
diethyl N-(2,4-dimethoxybenzyl)-amino-malonate

: 93591-43-6
(2S,3R)-2-bromo-3-(t-butyldimethylsilyloxy)butyryl chloride

: 93591-44-7
(2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

Guidance literature:: With triethylamine; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1246/bcsj.57.2135

Reference yield:

: 93591-42-5
(2S,3R)-2-bromo-3-(t-butyldimethylsilyloxy)butyric acid

: 93591-44-7
(2S,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-(t-butyldimethylsilyloxy)butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl ccloride / tetrahydrofuran / 16 h / 20 °C

2: Et₃N / tetrahydrofuran

With oxalyl dichloride; triethylamine; In tetrahydrofuran;
DOI:10.1246/cl.1983.169