2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

Base Information

Chemical Name:2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide
CAS No.:1400740-30-8
Molecular Formula:C₁₇H₁₇Cl₂FN₂O₃
Molecular Weight:387.238
Hs Code.:

Synonyms:2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

There total 10 articles about 2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 79-36-7
dichloroacethyl chloride

: 1085158-25-3
2-amino-3-fluoro-1-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-propan-1-ol

: 1400740-30-8
2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0
(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

: 1400740-30-8
2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: sulfuric acid / 18 h / 105 °C

4.2: 20 °C / pH 13

5.1: triethylamine / 1,1-dichloroethane / Reflux

6.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

7.2: 20 °C

8.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 16 h / 90 °C / Inert atmosphere

9.1: hydrogenchloride; water; acetic acid / 16 h / 100 °C / Sealed tube

10.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 8.1: Suzuki Coupling;

Reference yield:

: 4423-58-9
N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide

: 1400740-30-8
2,2-dichloro-N-{1-fluoromethyl-2-hydroxy-2-[4-(6-hydroxymethyl-pyridin-3-yl)-phenyl]-ethyl}-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: sulfuric acid / 18 h / 105 °C

3.2: 20 °C / pH 13

4.1: triethylamine / 1,1-dichloroethane / Reflux

5.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

6.2: 20 °C

7.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 16 h / 90 °C / Inert atmosphere

8.1: hydrogenchloride; water; acetic acid / 16 h / 100 °C / Sealed tube

9.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; diethylamino-sulfur trifluoride; sulfuric acid; water; hydrogen; potassium carbonate; acetic acid; triethylamine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 7.1: Suzuki Coupling;