ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

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Chemical Name:ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate
CAS No.:1228588-20-2
Molecular Formula:C₂₂H₃₀N₆O₄S
Molecular Weight:474.584
Hs Code.:

Synonyms:ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

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Chemical Property of ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

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Technology Process of ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

There total 4 articles about ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228588-19-9
ethyl-Nβ-[3-(pyrroldin-1′-ylmethyl)-benzyl]-β-alaninoate

: 38136-96-8
6-chloro-2-(methylsulfanyl)-5-nitropyrimidin-4-amine

: 1228588-20-2
ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

Guidance literature:: With triethylamine; at -78 - 23 ℃;

Reference yield:

: 1979-96-0
4,6-dichloro-2-(methylthio)-5-nitropyrimidine

: 1228588-20-2
ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; ammonia / tetrahydrofuran; methanol / 1.5 h / 0 °C

2: triethylamine / tetrahydrofuran / -78 - 23 °C

With ammonia; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm400815m

Reference yield:

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1228588-20-2
ethyl-Nβ-[4-amino-2-methylthio-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1.25 h / 23 °C

2: triethylamine / tetrahydrofuran / -78 - 23 °C

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/jm400815m