Technology Process of ethyl 2-benzoyl-4,5-dihydroxy-3-nitrobenzoate
There total 6 articles about ethyl 2-benzoyl-4,5-dihydroxy-3-nitrobenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-benzoyl-4-hydroxy-5-methoxy-3-nitrobenzoate;
With
pyridine; aluminum (III) chloride;
In
ethyl acetate;
at 77 ℃;
for 2h;
With
hydrogenchloride; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium chlorite; sulfuric acid / acetonitrile; water; dimethyl sulfoxide / 0.5 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C
4.1: titanium tetrachloride / dichloromethane / 0.5 h / 20 °C
5.1: nitric acid / dichloromethane / 0.33 h / 20 °C
6.1: pyridine; aluminum (III) chloride / ethyl acetate / 2 h / 77 °C
6.2: 20 °C
With
pyridine; aluminum (III) chloride; sodium chlorite; sulfuric acid; isopropylmagnesium chloride; nitric acid; titanium tetrachloride; potassium carbonate;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C
2.1: titanium tetrachloride / dichloromethane / 0.5 h / 20 °C
3.1: nitric acid / dichloromethane / 0.33 h / 20 °C
4.1: pyridine; aluminum (III) chloride / ethyl acetate / 2 h / 77 °C
4.2: 20 °C
With
pyridine; aluminum (III) chloride; isopropylmagnesium chloride; nitric acid; titanium tetrachloride;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
