2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1256385-49-5
Molecular Formula:C₂₈H₃₆BN₃O₄S
Molecular Weight:521.489
Hs Code.:

Synonyms:2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1256385-48-4
2-{5-[4-(5-bromo-thiophen-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 73183-34-3
bis(pinacol)diborane

: 1256385-49-5
2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In 1,4-dioxane; at 90 ℃; for 16h;
DOI:10.1021/jm401499g

Reference yield:

: 1007882-12-3
(S)-tert-butyl 2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1256385-49-5
2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane / 8 h / 90 °C

2: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; 1: |Suzuki Coupling;
DOI:10.1021/jm401499g

Reference yield:

: 1208007-67-3
(S)-tert-butyl 2-(6-bromo-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

: 1256385-49-5
2-(5-{4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)thiophen-2-yl]-phenyl}1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: C₄₂H₅₀N₈O₆S*2C₂HF₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane / 0.5 h / 110 °C / Microwave irradiation

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1.5 h / 20 °C

2.2: 0.75 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 1.1: |Suzuki Coupling;
DOI:10.1021/jm401499g