1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

Base Information

Chemical Name:1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate
CAS No.:1347493-31-5
Molecular Formula:C₂₃H₂₂ClN₂O₇PS
Molecular Weight:536.93
Hs Code.:

Synonyms:1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

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Chemical Property of 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

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Technology Process of 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

There total 5 articles about 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: dibenzyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl phosphate

: 1347493-31-5
1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 2h;
DOI:10.1021/jm500026w

Reference yield:

: 100200-99-5
potassium 2-methoxy-4-nitrophenolate monohydrate

: 1347493-31-5
1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium dihydrogenphosphate / water; acetonitrile / 3 h / 170 °C / 155149 Torr / Autoclave; Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

3.1: ethanol / 15 h / Reflux; Inert atmosphere

4.1: 1,2,4-Triazole / dichloromethane / 16 h / Reflux

4.2: 2.5 h / 20 °C

5.1: trifluoroacetic acid / water / 2 h / 20 °C

With 1,2,4-Triazole; sodium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm500026w

Reference yield:

: 945720-36-5
1-(2-methoxy-4-nitrophenoxy)-2-methylpropan-2-ol

: 1347493-31-5
1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

2.1: ethanol / 15 h / Reflux; Inert atmosphere

3.1: 1,2,4-Triazole / dichloromethane / 16 h / Reflux

3.2: 2.5 h / 20 °C

4.1: trifluoroacetic acid / water / 2 h / 20 °C

With 1,2,4-Triazole; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In ethanol; dichloromethane; water;
DOI:10.1021/jm500026w