(S)--2-(methoxymethyl)pyrrolidine

Base Information

Chemical Name:(S)--2-(methoxymethyl)pyrrolidine
CAS No.:78805-21-7
Molecular Formula:C₁₅H₂₁NO₃
Molecular Weight:263.337
Hs Code.:

(S)-<N-(R)-2-hydroxy-2-phenylpropionyl>-2-(methoxymethyl)pyrrolidine

Synonyms:(S)--2-(methoxymethyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)--2-(methoxymethyl)pyrrolidine

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Technology Process of (S)--2-(methoxymethyl)pyrrolidine

There total 4 articles about (S)--2-(methoxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 75-16-1
methylmagnesium bromide

: 113742-94-2
(S)-N-benzoylformyl-2-(methoxymethyl)pyrrolidine

: 78805-22-8
(S)--2-(methoxymethyl)pyrrolidine

: 78805-21-7
(S)--2-(methoxymethyl)pyrrolidine

Guidance literature:: With zinc(II) chloride; In diethyl ether; at -78 ℃; for 7h; Product distribution; other solvent, substrate, other metallorganics; stereocontrol;
DOI:10.1246/bcsj.63.1894

Reference yield: 10.0%

: 130412-44-1
(S)-N-pyruvoyl-2-(methoxymethyl)pyrrolidine

: phenylmagnesium bromide

: 78805-22-8
(S)--2-(methoxymethyl)pyrrolidine

: 78805-21-7
(S)--2-(methoxymethyl)pyrrolidine

Guidance literature:: In tetrahydrofuran; dichloromethane; 1) -78 deg C, 6h, 2) -50 deg C, 30 min;
DOI:10.1246/bcsj.63.1894

Reference yield:

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 78805-21-7
(S)--2-(methoxymethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) N-hydroxysuccinimide, 2) dicyclohexylcarbodiimide / 1) EE, 0 deg C, 2h, 2) RT, 64h

2: 10 percent / tetrahydrofuran; CH₂Cl₂ / 1) -78 deg C, 6h, 2) -50 deg C, 30 min

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1246/bcsj.63.1894