N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

Base Information

Chemical Name:N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide
CAS No.:157947-97-2
Molecular Formula:C₂₁H₂₃Cl₂N₃O₃
Molecular Weight:436.338
Hs Code.:

Synonyms:N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

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Chemical Property of N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

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Technology Process of N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

There total 9 articles about N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 158059-81-5
1-<(2S)-2-(4-nitrophenyl)-2-(methylamino)ethyl>pyrrolidine

: 157947-97-2
N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1021/jm00044a006

Reference yield:

: 14181-73-8
α-bromomethyl p-nitrophenyl ketoxime

: 157947-97-2
N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / CH₂Cl₂ / 4 h / Ambient temperature

2: 84 percent / BH₃*THF / tetrahydrofuran / 24 h / Heating

3: 87 percent / 24 h / Ambient temperature

4: 81 percent / BH₃*dimethyl sulfide / tetrahydrofuran / 2 h / Heating

5: 30 percent / pyridine / CH₂Cl₂ / 16 h / 5 °C

6: 53 percent / conc. HCl / 12 h / Heating

7: 71 percent / pyridine, DCC / CH₂Cl₂ / 12 h / 25 °C

With pyridine; hydrogenchloride; borane-THF; dimethylsulfide borane complex; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00044a006

Reference yield:

: 116508-51-1
(1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine

: 157947-97-2
N-methyl-N-<(1S)-1-(4-nitrophenyl)-2-(1-pyrrolidinyl)ethyl>-3,4-dichlorophenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) conc. H₂SO₄, NaNO₃, 2.) H₂O, 3.) pyridine

With pyridine; sodium nitrate; sulfuric acid; water; In dichloromethane;
DOI:10.1021/jm00044a006